Such protrusions of myelin lamellae into dendrites appear to have been first described by Antal and Szekely (1987) in frog spinal cord. Such protrusions may also be the source of profiles of dendrites that contain membranous components in their cytoplasm, the assumption being that such profiles arise when the protrusion from the myelin sheath is not in the plane of section. Some profiles of dendrites that show dendrites being invaginated by protrusions from myelin sheaths have also been encountered ( Fig. Since the cytoplasm is electron dense it is assumed that these are profiles of dendrites that are degenerating. Such profiles are identified as belonging to dendrites because they are synapsing with axon terminals. Some profiles of dendrites are electron dense and shrunken ( Fig. Profiles of some dendrites in the aging cerebral cortex have membrane bound vacuoles in their cytoplasm (Figs. That these profiles belong to dendrites is shown by the fact that their bounding plasma membrane can be involved in the formation of synapses with axon terminals.ģ. 2.2 may be an early stage in degeneration, leading to the formation of profiles of dendrites that are almost completely devoid of organelles ( Fig. The profiles of dendrites such as shown in Fig. Profiles such as these are common in layer 1 of the aging cortex, a layer which becomes thinner with age as the apical tufts of pyramidal neurons retract and degenerate.Ģ. The profiles of some dendrites in the cortices of old monkeys show a cytoplasm devoid of organelles beyond a few microtubules beneath the plasma membrane ( Fig. Nevertheless, unusual images of dendrites that probably reflect the effects of age are sometimes encountered and some of these images are as follows:ġ. Although no systematic studies have been made of the effects of age on the fine structure of dendrites, most profiles of dendrites in electron micrographs show no or few obvious age changes. It is known that with age dendrites, especially those in the apical tufts of pyramidal cells, retract and degenerate. Consequently profiles of their dendrites have more regular shapes and these dendrites receive most of their synapses on their shafts. In contrast to the dendrites of pyramidal neurons, the dendrites of nonpyramidal, inhibitory neurons have smoother outlines, with few or no dendritic spines. The dendritic spines receive the majority of axon terminals synapsing with dendrites of pyramidal and spiny stellate neurons, but electron microscopic images that show the entire lengths of dendritic spines are not commonly encountered and have to be sought. The dendrites of the excitatory pyramidal cells are also profusely decorated with dendritic spines so that profiles of their dendrites tend to have somewhat irregular outlines. They travel singly through the neuropil and have a cytoplasm that contains regularly spaced microtubules, ribosomes and rough endoplasmic reticulum, mitochondria, and long cisternae of smooth endoplasmic reticulum ( Figs. Dendrites are processes that extend from the cell bodies of cortical neurons.
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"We shouldn't even be thinking about the reason that patients are giving when they seek to access care. "We need to make sure we're training prescribers and their teams in addressing the systemic biases that this research highlights," says Lagisetty, a general internal medicine physician at Michigan Medicine, the University of Michigan's academic medical center. MORE FROM MICHIGAN: Sign up for our weekly newsletter , hopes that her team's new findings could help primary care clinics look at their practices regarding existing or prospective new patients. The Michigan Medicine primary care provider and health care researcher who led the new study, Pooja Lagisetty, M.D., M.Sc. Simulated patients who said their doctor or other primary care provider had retired were more likely to be told they could be accepted as new patients, compared with those who said their provider had stopped prescribing opioids to them for an unknown reason, according to the paper in the journal Pain. Stigma against long-term users of prescription opioids, likely related to the prospect of taking on a patient who might have an opioid use disorder or addiction, appears to play a role, the Michigan Medicine research suggests. People who take opioid medications for chronic pain may have a hard time finding a new primary care clinic that will take them on as a patient if they need one, according to a new "secret shopper" study of hundreds of clinics in nine states across the country. Office of Graduate and Postdoctoral Studies.Institute for Healthcare Policy & Innovation. Elizabeth Weiser Caswell Diabetes Institute.Computational Medicine & Bioinformatics.Alfred Taubman Medical Research Institute Leadership and Enrichment for Academic Diversity (LEAD).Implicit Bias Training for Community Members.Implicit Bias Training for Michigan Medicine.Health Equity and Quality Scholars Program.Frequently Asked Questions About Sponsorship.
“I could have seen (Hale) doing children’s books for a living,” said Colomy. Hale’s illustration work was “whimsical” and “childlike,” Colomy said, describing the student as small and quiet. “Everything I saw from her was very professional.” “She was very quiet, very good at school, very good at art, very good at her illustration,” she said. “She was an amazing illustrator.”Ĭolomy described Hale as confident, but not an outwardly confident or boisterous person. “After that first day, as soon as assignments started being turned in, Audrey came out of the gate at a 10,” Colomy said Wednesday afternoon. Hale had to leave the classroom, Colomy said, adding it was Hale’s only outburst. “From what I saw on her social, (Hale) was suffering,” Colomy said.Ĭolomy also described Hale becoming upset on the first day of class when unable to figure out how to set up a password. “The only thing I would see (Hale) post about was this girl,” said the teacher, Maria Colomy, telling CNN she taught Hale for two semesters in 2017 at Nossi College. Over the last year, Hale posted on Facebook about the death of a girl with whom Hale apparently played basketball, as well as a request to be referred to by the name Aiden and male pronouns, a former teacher told CNN. My wife and I have been crying all day about it,” adding that Hale “was really shy and really good.”įormer teacher: Shooter wrote on Facebook about grieving teammate Hale won “Most Improved” and “Class Participation” awards from Nossi, according to web posts by the college.Ī former vice president of the college, Byron Edwards, described Hale as, “… the sweetest little thing. One image included the phrase, “To Be A Kid (forever and ever).” A LinkedIn profile says Hale worked as a freelance graphic designer and a part-time grocery shopper.Īn online portfolio that appears to show a collection of Hale’s work includes images of professional logos, cartoon animals and an apparent self-portrait. Hale graduated from Nossi College of Art & Design in Nashville last year, the school’s president confirmed to CNN. Hale graduated from a Nashville art college We went all the way to the city (championships), so it was a really good year for us. “We got to see her grow in her skill on the court,” Patton told CNN on Tuesday evening. When they were on the team together, Patton said, Hale was “very quiet, very shy,” and they joked around together. Take a moment to stroll the towers and breath in that fresh sea mist infused air. Mountain Climbing Game 'Insurmountable' has released on Steam. Exploration: Secret rooms, hidden passages, charming landscapes.Opt for the path that suits your current build, your play style, or just your mood. Nonlinear progression: Sewers, Ossuary or Ramparts? Once unlocked, special permanent abilities allow you to access new paths to reach your objective.2D Souls-lite Action: Tough but fair combat, the iconic dodge roll, more than 90 weapons and spells with unique gameplay… The unforgiving action wed to the absence of any kind of safety net makes for an adrenaline pumping ride each and every run.RogueVania: The progressive exploration of an interconnected world, with the replayability of a rogue-lite and the adrenaline pumping threat of permadeath.The disc contains version 1.0 of the game, subsequent free updates will be automatically updated when your device is connected to the internet. Patience, you’ll get better!… eventually. All the games everyone is talking about PS5 God of War bundle Get the PlayStation 5 console with wireless controller and God of War Ragnarök game. PS5 499.99 PS5 Digital Edition 399.99 Disc-free gaming Consoles will be viewable when inventory is available. Plus, mutations and scrolls allow you to build and customize your character differently with each and every run.Īt the end of the day though, it’s YOUR skills as a player that matter most! Roguelites are about constantly sharpening your skills, until what was an insurmountable obstacle becomes a walk in the park. Ultimate gaming wireless controller for PS5 now available. A large variety of swords, bows and of course spells, but also whips, grenades and turrets, each one with its own unique twist. Speaking of weapons, Dead Cells features a plethora of ways to slay your enemies. However, you keep some of your progress for successive runs new paths you’ve unlocked, access to new levels, mutations, abilities and weapons. You either vanquish the final boss in one go, or you try again. Tough but fair combat, responsive controls, challenging foes, permadeath and of course, the emergency panic roll to get you out of trouble, make for a demanding, visceral and cathartic action game.Įxperience a Roguevania, mixing an interconnected world, branching paths and unlockable skills with the constant adrenaline-pumping threat of permadeath. Dead Cells puts you in control of a failed alchemic experiment trying to figure out what's happening on a sprawling, ever-changing and seemingly cursed Island. Although this is wider than you might see on other wired security cameras, it's narrower than the 130º average on most wireless cameras. We're not big fans of the cameras' narrow field of view (100º), which limits how much they can see. This type of night vision is more effective than most Wi-Fi security cameras, which illuminate about 25 feet on average. Each camera comes equipped with powerful infrared LEDs that give it up to 100 feet of night vision range. The four cameras in our Night Owl system are weatherproof, so you can use them indoors or outdoors. Still, the lag was less apparent compared to a wireless camera like the Arlo Pro 4, probably because there's no Wi-Fi involved on the sending end. When you watch a livestream on the mobile app, you can expect a short lag depending on your internet speed. Still, renters in apartments (like the small apartment where we tested) might see a little motion blurring close to the camera with people walking directly in front of it. If you view the video on a monitor connected to the DVR, it looks crisp without any noticeable motion blur at a distance. Compared to wireless cameras like the Ring Stick Up Cam and Wyze Cam Outdoor, the quality doesn't hold up considering those are easier to install. With Night Owl in particular, we found the color wasn't great in dim rooms and just decent in bright spaces. (We didn't test this, but it's true for most wired surveillance systems.) In our case, the included cameras topped out at 1080p, which is standard for security cameras these days. Still, we suspect it supports a variety of wired add-on cameras with lower resolutions as well. The DVR supports recording resolutions up to 1080p. Video quality is a tricky subject when dealing with DVRs like the one Night Owl uses. After versions with mailboxes having elements like an eagle’s wings or a tiger’s tail, I settled on a mailbox with old fashioned airplane wings, tilting up as if taking flight. Also, though our products for kids have a strong digital and online component, we wanted to impart of bit of nostalgia for the joy kids feel when getting a special package in the mail, which is how our core products are delivered. I also wanted to include a bit of adventure in the logo, so knew it needed to take flight or have some sort of adventurous element. Being that my company is called The Adventurous Mailbox, I knew I wanted to have a mailbox front and center. Our logo needed to communicate a lot, so it took a lot of fine tuning to get it right. Our company sells series of adventure books introducing world cultures to kids that arrive in very cool packages from abroad. Thanks to Julie Stobbe, Mind Over Clutter If you have your logo in many formats than when an advertiser, sign maker, clothing designer, needs your logo you will be able to avoid additional graphic designer charges in the future. One piece of advice I would like to include is when you are working with a graphic designer get your logo in every possible format you can think of, jpeg, gif, ai, DST, ESP etc and in colour and in black and white. From that unofficial poll I made my choice and I have not changed it. The graphic designer gave me 4 versiMind Over Clutterons of my logo and then I asked friends, exercise participants, networking group members which one they liked best. My next step was to give the sketch to my web designer, Janet Barclay Organized Assistant, because part of my web package included a graphic designer creating the logo. She started to sketch ideas and eventually and she came up with the design. I went to a friend that was an artist and we brainstormed some ideas for my logo. #3 – Get Your Logo in Every Possible FormatĪs a solo entrepreneur my budget was very small when I started Mind over Clutter. We use our logo across lots of different media so we chose to use a circle as this could then be used on its own as a sub logo as well as with the text. We rounded the edges of the plane to ensure it still looked playful and not too sharp and also when the logo is scaled down it still prints cleanly, which can be lost with sharp edges. As a designer agency we spent along time creating this logo and we still love it. Strafe is also a German word for power (Strafen) and we like the idea of efficiency that Germany in known for. With “Strafe” settled on we wanted to keep the logo fun as we’re both young, so we decided to use a more playful option and chose a paper plane. We liked the idea that after people worked with us we could change the direction of their business for the good. Our name is Strafe Creative and to “strafe” is when a fighter jet quickly changes direction. Thanks to Scott Gabrielson, Oliver Cabellīefore we began the logo we knew the choice of name was super important for us, when we first set up we struggled for names and I randomly started going through Wikipedia and came across fighter jets. By bringing in elements such as round corners and a traditional type face, we were able to come up with something that was unique to our brand. We spent months analyzing competitors logos and brands that we inspire, and tried to determine what make us feel a certain way. Our brand is also a bit playful, which brought on an additional challenge. Oliver Cabell is a new fashion brand that is disrupting the traditional market while still holding true to its industry, fashion, so we needed to create a logo that balanced these elements. # 1 – Balancing the Elements of the BrandĬoming up with a business logo was a very iterative process for us. We decided to ask some entrepreneurs and business owners how they decided a logo for their business and any tips they had for other business owners. For entrepreneurs and business owners it is sometimes not an easy and simple process. Selecting a logo is a big decision because it establishes the brand of your company. +7 (495) 22 900 22 ext.What is ABBYY Finereader and how does it work?ĪBBYY Finereader is an optical character recognition (OCR) software that facilitates one-click document conversion into PDF formats. For more information, visit Media Contacts: ABBYY is headquartered in Moscow, Russia, with offices in Germany, the United States, Ukraine, the UK, Japan and Taiwan. ABBYY OCR applications are shipped with equipment from the world’s top manufacturers such as BenQ, Epson, Fujitsu, Fuji Xerox, Microtek, Panasonic, Plustek, Toshiba, and Xerox. Companies that license ABBYY technologies include BancTec, Canon, EMC/Captiva, Hewlett-Packard, Microsoft, NewSoft, Notable Solutions, Samsung Electronics and more. ABBYY products are used in large-scale government projects such as those of Australian Taxation Office, Lithuanian Tax Inspectorate, Ministry of Education of Russia, Ministry of Education of Ukraine, and Montgomery County Government of the USA. Paper-intensive organizations from all over the world use ABBYY software to automate time- and labour-consuming tasks and to streamline business processes. Its products include the ABBYY FineReader line of optical character recognition (OCR) applications, ABBYY FlexiCapture line of data capture solutions, ABBYY Lingvo dictionary software, and development tools. The software also controls the data being printed out.ĪBBYY is a leading provider of document recognition, data capture and linguistic software. InfoWatch Device Monitor allows corporate security officers to control both copying of confidential documents or their parts into mass storage devices (floppy, CD/DVD, external USB devices or external medias connected via various ports - USР ’ LPT, COM), and the use of such WTPs, as IRDA and Bluetooth. Currently, the company is strengthening its positions on the European market. InfoWatch’s products minimize the risk of data leakage and deletion, sabotage, industrial espionage and other reckless and illegal activities relating to corporate information committed by employees. With 8 years of experience in information security, the company owns 70% of the Russian market of data security solutions. InfoWatch is an expert in developing data leakage protection software. ABBYY FineReader technologies will help to make DLP solutions more versatile to monitor any data regardless of the types of documents,” explained AndreyIsaev , Director of the Technology Products Department at ABBYY. We are rather glad that InfoWatch has chosen our recognition technologies for data security optimization. “Integration of OCR technologies into data leakage protection software is a very new and important field for us. The comprehensive language coverage and high quality recognition results from ABBYY together with advanced DLP know-hows from InfoWatch make a successful combination to prevent any data leakage activities. Monitoring of text on images is carried out by ABBYY FineReader recognition technologies, which ensure superior recognition accuracy of data on printed texts and images, and support 195 languages, including Chinese, Japanese and Korean (CJK). We believe that these two complementary technologies are integrated for user’s benefit,” said Svetlana Ashkinazi, Director of Product Department at InfoWatch. “We are very glad to provide our customers with better data security. With InfoWatch Device Monitor and ABBYY’s award-winning OCR technologies, a new level of confidential information security has been achieved. However, there remained a threat of information leakage, as it was possible to copy files into storage devices and print out scanned images of confidential text, digital photos of important paper documents, and PDF files without a text layer. If the confidential information is detected, then copying and printing of the document can be blocked.Įarly DLP products were able to monitor data both in some types of PDFs and text documents created in MS Word and other word processor programs. The control system of InfoWatch Device Monitor allows making shadow copies of all analyzed documents and texts in corporate network and send these copies to the central server, where it is decided, whether certain data contain confidential information or not. Moscow, Russia (December 10, 2009) - ABBYY, aleading provider of document recognition, data capture and linguistic software,and InfoWatch,an expert in developing data leakage protection (DLP) software, announced their integration of ABBYY FineReader recognition technologies into InfoWatch Device Monitor, a DLP application preventing confidential documents and their parts from being printed out and copied into various mass storage devices by employees. Now InfoWatch Device Monitor Traces Confidential Information on Printed and Copied Images Rather than the greenhouse gas emissions associated with production, carbon footprints focus on the greenhouse gas emissions associated with consumption. Carbon footprint calculationĬarbon footprints are different from a country’s reported per capita emissions (for example, those reported under the United Nations Framework Convention on Climate Change). In contrast, a carbon footprint is usually expressed as a measure of weight, as in tons of CO 2 or CO 2 equivalent per year. It includes environmental impacts, such as water use and the amount of land used for food production. An ecological footprint is the total area of land required to sustain an activity or population. The carbon footprint concept is related to and grew out of the older idea of ecological footprint, a concept invented in the early 1990s by Canadian ecologist William Rees and Swiss-born regional planner Mathis Wackernagel at the University of British Columbia. In addition, the carbon footprint concept also often includes the emissions of other greenhouse gases, such as methane, nitrous oxide, or chlorofluorocarbons (CFCs). 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